The VariantPlex Complete Solid Tumor panel is a targeted next-generation sequencing (NGS) assay that simultaneously detects and characterizes copy number variations (CNVs), single-nucleotide variants (SNVs), insertions and deletions (indels), microsatellite instability (MSI) status, and tumor mutational burden (TMB) in 430 cancer-implicated genes, including non-small cell lung cancer, colorectal cancer, breast cancer, bladder cancer, gastric cancer, pancreatic cancer, prostate cancer, ovarian and uterine cancers, CNS cancers, cholangiocarcinoma and melanoma. Representing our most comprehensive DNA-based assay for solid tumor research, this newly expanded panel was thoughtfully designed based on guidelines, literature, and customer input, and offers analytically sensitive variant detection even with low sample input.